Relatively uncommon in the vulva



Lipoma1 is a relatively common hamartoma (benign, focal malformation of normal tissue) of fatty subcutaneous tissue.




Fat cells with the same morphology as normal fat cells cluster within a connective tissue framework.2

Symptoms and clinical features

The patient notices a mass in the vulva that has grown in size but is usually asymptomatic.

On the labium major, there is a soft, sessile, or pedunculated mass varying in size from 1 cm to several centimeters in diameter.


Very large lesions may be ulcerated.


Diagnosis is clinical and confirmed by biopsy if necessary.

Pathology/Laboratory Findings

On biopsy, mature adipose tissue with a thin fibrous capsule is found.3

Differential diagnosis

Differential diagnosis includes hemangioma, fibroma, and Bartholin’s cyst.


Excision of the mass is necessary if it is symptomatic.


  1. Fisher BK, Margesson, LJ. Genital Skin Disorders: Diagnosis and Treatment. Mosby, Inc. 1998. 204.
  2. Wolff K and Johnson RA. Fitzpatrick’s Color Atlas & Synopsis of Clinical Dermatology, sixth edition. 2009, New York. McGraw Hill Medical. 224.
  3. Heller DS, Wallach RC, ed. Vulvar disease; a clinicopathological approach. Informa Healthcare. 2007. 156.